Databases in the
Elisabeth Gasteiger, July
General remark: SWISS-PROT is highly
cross-referenced, so make use of these cross-references to get from SWISS-PROT
to corresponding entries in other databases!
- Look for the amino acid sequence of
human carbonic anhydrase 2 in SWISS-PROT.
- Retrieve the corresponding nucleic acid sequence entries
from the EMBL and GenBank databases. (Why are there more than
- Look at a PDB file. (Why are there more than one?)
- Find the chromosomal location of human
carbonic anhydrase 2
- via MIM
(Mendelian Inheritance inMan)
- via GDB (Genome Data
- Is carbonic anhydrase known for maize and drosophila?
(possible appproaches: SWISS-PROT/TrEMBL or EMBL or the genomic databases
MaizeDb/Flybase (as the gene might be known but not
- Search for the SWISS-PROT entry corresponding to the
yeast gene RPL36B.
- Follow the link to SGD
(Saccharomyces Genome Database) to see the chromosomal
Retrieve the SGD entry
corresponding to the gene that is the second next gene in direction 5' on the
same strand of the chromosome.
- Follow the link to the YPD
- Find the subcellular location of the
- Follow the link to
- Have a look at the domain structure in
the PRODOM database and retrieve a list of proteins sharing at least one domain
with this protein.
Find a database of CFTR mutations (CFTR is the gene for
cystic fibrosis) in the Web
- Find the 'teashirt' gene in FlyBase
- Retrieve, via FlyBase, the corresponding
SWISS-PROT, EMBL and TRANSFAC (transcription factor db) entries.
- Go to the 'Genome Net' server in Japan
- Look for a database called "KEGG"
- In KEGG, search for the enzyme with the
EC (Enzyme classification) number EC 18.104.22.168
Retrieve - the ENZYME entry (on
ExPASy) via KEGG
- the SWISS-PROT entry OXO1_HORVU via
- the corresponding PROSITE entry via